Various 32 bit (so far I have only tried Linux) guests hang after a short while inside my 64 bit host. The cursor disappears (is recoverable when moving out of the guest window or by clicking the Host key) and the guest is totally unresponsive. This happens both on guests with and without the guest additions installed. I have only seen this happen when trying to download system updates, i.e. when there is network activity. I have not seen this happen with 64 bit Linux hosts.
The host runs Fedora 10 x86_64, and I recently updated from VirtualBox 2.2 to 3.0.0 (64 bit version). Using 2.2 I have had no problems running the guests. I don't remember which 2.2 I had (at least 2.2.2).